Therapeutic for Glioblastoma Multiforme and Other Cancers

Glioblastoma Multiforme (GBM) is the most common and malignant type of primary brain tumor in humans. Despite existing conventional therapies, including initial surgical resection followed by chemotherapy and radiation, GBM is currently incurable with a median survival of approximately 15 months and a two-year survival of 30%.

Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seek licensing and/or co-development research collaborations for a novel therapeutic technology that treats Glioblastoma Multiforme (GBM) using induced electric fields applied to the brain in a non-invasive and non-contacting manner via a current generator and a customized array of coils placed over the scalp. The proposed mechanism of the tumor treating fields (TTFs) action is the disruption of mitotic events occurring in rapidly dividing cancer cells using induced oscillating electric fields. Some proposed advantages over existing methods of TTF delivery are its ease of use, a potential for whole-brain coverage, and a reduced likelihood of skin rashes, for instance, that could be caused by electrodes being applied directly on the scalp.

Potential Commercial Applications: Competitive Advantages:
  • Treatment of patients with Glioblastoma Multiforme (GBM)
  • Clinical research device for understanding cancer cell proliferation in in vitro
  • Possible application to other cancers
  • Biological research tool to study mechanisms of electric field effects on mitosis and other cell and tissue processes
  • Useful in improving effectiveness and enhancing delivery of adjuvant therapies, including chemotherapy, radiation therapy, immunotherapy, etc.
  • Portable, painless, and easy to operate
  • No skin rashes that can occur with current electrodes
  • Potential for whole-brain coverage
  • Ability to use method shortly after brain surgery is performed

Development Stage:
  • Early-stage
  • Prototype


Peter Basser (NICHD)  ➽ more inventions...

Intellectual Property:
US Application No. 15/125,079
US Application No. 61/954,494
PCT Application No. PCT/US2015/021066
EP Application No. 15712513.9

Silva S, et al. Elucidating the mechanisms and loci of neuronal excitation by transcranial magnetic stimulation using a finite element model of a cortical sulcus. [PMID 18783986]
Salvador R, et al. Determining which mechanisms lead to activation in the motor cortex: a modeling study of transcranial magnetic stimulation using realistic stimulus waveforms and sulcal geometry. [PMID 21035390]
Miranda PC, et al. Tissue heterogeneity as a mechanism for localized neural stimulation by applied electric fields. [PMID 17804884]
Miranda PC, et al. The electric field induced in the brain by magnetic stimulation: a 3-D finite-element analysis of the effect of tissue heterogeneity and anisotropy. [PMID 12943275]
Basser PJ. Focal magnetic stimulation of an axon. [PMID 7927380]
Miranda PC, et al. Modeling the current distribution during transcranial direct current stimulation. [PMID 16762592]

Collaboration Opportunity:

This invention is available for licensing and co-development. Please contact John D. Hewes at 240-276-5515 or for additional information.

Licensing Contact:
Surekha Vathyam, Ph.D.
Phone: 240-276-6865

OTT Reference No: E-187-2012/0
Updated: Feb 13, 2018