Methods for the Simultaneous Detection of Multiple Analytes


CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific antibodies bound to fluorescent beads, allowing for simultaneous single tube capture and detection of multiple antigens in one rapid, high-throughput flow cytometry assay. Such technology has an extremely wide range of useful applications, including but not limited to complex serotyping investigations for vaccine development and formulation, as a tool for rapid clinical prognosis or diagnosis, and the assay can be formatted as a kit for any number of laboratory research uses.

Potential Commercial Applications: Competitive Advantages:
  • Complex serotyping and/or multi-antigen composition investigations
  • Tool for clinical diagnosis or prognosis of a disease or infection
  • Tool for basic research
 
  • Rapid flow cytometry assay
  • Simultaneous detection of multiple different antigens and antibodies
  • Excellent for high-throughput usage
  • Provides a reliable, reproducible measurements of serotype-specific antigens within a sample
  • Technology particularly well-developed for addressing S. pneumoniae serotyping concerns


Development Stage:
In vitro data available

Inventors:

Joseph Martinez (CDC)  ➽ more inventions...

George Carlone (CDC)  ➽ more inventions...


Intellectual Property:
U.S. Pat: 7,659,085 issued 2010-02-09
US Application No. 60/192,712
US Application No. 10/259,907

Licensing Contact:
Karen Surabian, J.D., M.B.A.
Email: karen.surabian@nih.gov
Phone: 301-594-9719

OTT Reference No: E-142-2013/0
Updated: Feb 6, 2014