Chlamydial Vaccine Technologies


The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia is also the leading cause of preventable blindness in the world. Despite increased surveillance, prevalence continues to increase, and the need to develop an effective chlamydial vaccine remains.

Technologies:
1. A plasmid-deficient Chlamydia trachomatis strain which was shown to be a safe, immunogenic, and protective live attenuated vaccine in a nonhuman primate model.
2. A Chlamydia trachomatis polymorphic membrane protein D (PmpD) based subunit vaccine.
3. A live-attenuated Chlamydia trachomatis plasmid vector deficient in virulence genes, pgp3 and pgp4, which can be used to vaccinate against chlamydia as well as other against other bacterial and viral mucosal pathogens.

Potential Commercial Applications: Competitive Advantages:
  • Chlamydia trachomatis vaccine or therapeutic.
  • Vaccine platform technology for mucosal viral and bacterial pathogens.
 
  • Coverage against multiple serovars.
  • Promising preclinical data.


Inventors:

Harlan Caldwell (NIAID)  ➽ more inventions...

Deborah Crane (NIAID)  ➽ more inventions...

Laszlo Kari (NIAID)  ➽ more inventions...


Intellectual Property:
US Application No. PCT/US2007/001213
PCT Application No. 12/087,952
US Application No. 15/043,975
US Application No. 61/753,320
US Application No. PCT/US2014/011799
PCT Application No. 14/761,520
Research Material – Patent protection is not being pursued for this technology. (IC Reference No. 2011-028)

Publications:
Olivares-Zavaleta N, et al. [PMID 24711617]
Kari L, et al. [PMID 21987657]
Song L, et al. [PMID 23319558]
Carlson JH, et al. [PMID 15557630]
Caldwell HD, et al. [PMID 12782678]
Swanson KA, et al. [PMID 19001072]
Crane DD, et al. [PMID 16446444]

Licensing Contact:
Wade Green,
Email: wade.green@nih.gov
Phone: 301-761-7505

OTT Reference No: E-031-2006-0
Updated: Mar 28, 2018