Technologies related to Central Nervous System

MADCO-Accelerated Multidimensional Diffusion MRI
Ref: E-173-2016/0 | Updated: Dec 14, 2017
Stable Cell Line for Enhanced Expression and Production of Recombinant Human Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)
Ref: E-216-2017/0 | Updated: Dec 5, 2017
Human FPRL1 / FPR2 cDNA
Ref: B-008-1995/0 | Updated: Dec 4, 2017
Human fMLP Receptor / FPR cDNA
Ref: B-007-1995/0 | Updated: Dec 4, 2017
cGAP-PNA Multivalent Ligand Display at the Nanoscale
Ref: E-761-2013/0 | Updated: Apr 18, 2017
M5 Muscarinic Receptor Knockout (Chrm5tm1Jwe) Mouse Model for Neurological Studies
Ref: E-110-2012/0 | Updated: Apr 17, 2017
Methods for Improving Drug Delivery to the Central Nervous System
Ref: E-179-2016/0 | Updated: Feb 13, 2017
Methods of Making and Using Dopamine D3 Receptor Selective Antagonists/Partial Agonists
Ref: E-053-2016/0 | Updated: Mar 8, 2017
Long Acting Therapeutic Conjugates with Evans Blue
Ref: E-143-2015/0 | Updated: Jun 27, 2016
Gene Therapy for Niemann-Pick Disease Type C
Ref: E-185-2014/0 | Updated: Apr 18, 2016
Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Ref: E-208-2015/0 | Updated: Jan 4, 2016
Microfluidic Device and System for Analyzing Shear Forces in Blast-Induced Traumatic Brain Injury
Ref: E-001-2015/0 | Updated: Nov 30, 2015
Novel Isoform of KCNH2 for the Treatment of Schizophrenia
Ref: E-245-2006/0 | Updated: Aug 17, 2016
Detection and Discrimination of Classical and Atypical L-Type BSE Strains by RT-QuIC
Ref: E-048-2015/0 | Updated: Sep 23, 2015
mNFHcre Transgenic Mice
Ref: E-293-2009/0 | Updated: Aug 10, 2015
A Novel Adeno-Associated Virus for Gene Therapy
Ref: E-175-2015/0 | Updated: Nov 1, 2017
Magnetic Resonance Magnification Imaging
Ref: E-252-2014/0 | Updated: Jan 12, 2017
Device for Selective Partitioning of Frozen Cellular Products
Ref: E-173-2009/0 | Updated: Jun 29, 2015
Development of GPR124 Wildtype and Knockout Brain Endothelial Reporter Cells
Ref: E-079-2015/0 | Updated: Dec 12, 2017
Novel Dopamine D2 Receptor Antagonists and Methods of Their Use
Ref: E-030-2013/0 | Updated: Sep 5, 2017
89Zr-Oxine Complex for In Vivo PET Imaging of Labelled Cells and Associated Methods
Ref: E-080-2014/0 | Updated: Dec 2, 2015
Mobile Instrumentation for the Detection and Sampling of Aerosol Particles
Ref: E-026-2014/0 | Updated: Nov 14, 2014
Miniature Serial Microtome for Block-Face Imaging
Ref: E-121-2014/0 | Updated: Dec 16, 2015
A Novel Demodulation System in X-ray Imaging
Ref: E-113-2013/0 | Updated: Sep 9, 2015
Monitoring the Effects of Sleep Deprivation Using Neuronal Avalanches
Ref: E-345-2013/0 | Updated: Aug 17, 2016
Multifunctional RNA Nanoparticles as Therapeutic Agents
Ref: E-765-2013/0 | Updated: Nov 14, 2016
Treating or Inhibiting JC Polyomavirus Infection and JC Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy
Ref: E-549-2013/0 | Updated: Apr 15, 2014
Engineering Neural Stem Cells Using Homologous Recombination
Ref: E-762-2013/0 | Updated: Apr 14, 2014
Compositions for Modification of Genomic DNA and Exogenous Gene Expression
Ref: E-763-2013/0 | Updated: Apr 14, 2014
Human iPSC-Derived Mesodermal Precursor Cells and Differentiated Cells
Ref: E-342-2013/0 | Updated: Mar 18, 2014
Lead Detection Wipes for Potentially Contaminated Surfaces
Ref: E-336-2013/0 | Updated: Mar 7, 2014
Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Response
Ref: E-236-2013/0 | Updated: Feb 19, 2014
Cylindrical Handle Dynamometer for Improved Grip-Strength Measurement
Ref: E-143-2013/0 | Updated: Feb 6, 2014
Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology Training and Analysis
Ref: E-228-2013/0 | Updated: Feb 6, 2014
Methods of Retaining Methylation Pattern Information in Globally Amplified DNA
Ref: E-243-2013/0 | Updated: Feb 6, 2014
Therapeutic, Bifunctional Janus Microparticles with Spatially Segregated Surface Proteins and Methods of Production
Ref: E-457-2013/1 | Updated: Jan 28, 2014
Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
Ref: E-292-2013/0 | Updated: Feb 17, 2016
Fluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification
Ref: E-252-2013/0 | Updated: Jan 27, 2014
Use of Detector Response Curves to Optimize Settings for Mass Spectrometry
Ref: E-157-2013/0 | Updated: Jan 20, 2014
Methods of Treating or Preventing Pruritis (Itch)
Ref: E-485-2013/0 | Updated: Jan 16, 2014
Generation of Artificial Mutation Controls for Diagnostic Testing
Ref: E-255-2013/0 | Updated: May 24, 2016
Diffusion Through Skull as Route of Delivery for Treatment of Brain Injury and Disease
Ref: E-025-2012/0 | Updated: Aug 6, 2013
Potent and Selective Analogues of Modafinil and Uses Thereof
Ref: E-073-2013/0 | Updated: Oct 11, 2017
Predicting Age of Onset of Niemann-Pick Disease
Ref: E-060-2013/0 | Updated: Jun 21, 2013
Live Attenuated RSV Vaccines Based on Codon-Pair Deoptimization
Ref: E-080-2013/0 | Updated: Jun 6, 2013
Derivatives of Docosahexaenoylethanolamide (DEA) for Neurogenesis
Ref: E-070-2012/0 | Updated: Nov 1, 2017
SIRT2 Inhibitors as Novel Therapeutics for Myocardial Infarction and Ischemic Stroke and to Prevent Necrosis
Ref: E-003-2013/0 | Updated: Jan 23, 2013
Axon Regeneration After Brain or Spinal Cord Injury
Ref: E-214-2012/0 | Updated: Nov 21, 2012
Small Molecule MRS5474 with Anticonvulsant Activity for Treatment of Epilepsy
Ref: E-285-2008/1 | Updated: Aug 31, 2016
Cyclodextrins as Therapeutics for Lysosomal Storage Disorders
Ref: E-050-2012/0 | Updated: Nov 18, 2015
Glucocerebrosidase Non-inhibitory Chaperones for the Treatment of Gaucher Disease, Parkinson's Disease, and Other Proteinopathies
Ref: E-144-2012/0 | Updated: Apr 16, 2014
Improved Monoclonal Antibodies Against Neuregulin 2
Ref: E-188-2012/0 | Updated: Nov 6, 2012
Glial Cell Line-Derived Neurotrophic Factor Opposite Strand (GDNFOS) for Treatment of Neurodegenerative Diseases
Ref: E-044-2012/0 | Updated: Mar 8, 2017
Treatment of Acute and Chronic Neurological Disorders Using GLP-1, Exendin-4 and Analogs
Ref: E-049-2001/0 | Updated: Oct 5, 2015
Lenalidomide Analogs for the Treatment of Neurodegenerative Disorders and Cancer
Ref: E-045-2012/0 | Updated: Dec 14, 2017
Novel Radio-labeled Agents for Imaging Alzheimer's Disease-associated Amyloid
Ref: E-225-2011/0 | Updated: Aug 17, 2016
Human Soluble Receptor for Advanced Glycation End Products (sRAGE) for Treating Vascular Disease, Injury, or Inflammation
Ref: E-165-2011/0 | Updated: Jun 29, 2017
Biomarkers for Niemann-Pick Disease Type C and Related Disorders of Oxysterol Accumulation
Ref: E-302-2011/0 | Updated: Jul 5, 2013
Encapsulated N-Acetylmannosamine or N-Acetylneuraminic Acid as a Therapeutic Agent for Increasing Sialylation in Certain Muscular Atrophies, Kidney Disorders, Cancers or Poor Immune Function
Ref: E-270-2011/0 | Updated: Sep 21, 2015
Therapeutic Approach to Neurodegenerative Disorders Using a TFP5-Peptide
Ref: E-144-2010/0 | Updated: May 5, 2016
Use of Sterculic Acid to Treat Choroidal Neovascularization
Ref: E-092-2010/0 | Updated: Jan 24, 2018
Phantasmidine, a Nicotinic Receptor Agonist for the Treatment of Addiction and Neurological Disorders
Ref: E-125-2010/0 | Updated: Sep 20, 2010
Improved Pepper Spray for Repellency and Incapacitation
Ref: E-048-2010/0 | Updated: May 23, 2016
Treatments for Smith-Lemli-Opitz Syndrome and Other Disorders of Cholesterol Biosynthesis
Ref: E-206-2007/0 | Updated: Jul 13, 2010
High-yield Methods of Producing Biliverdin
Ref: E-040-2004/0 | Updated: Jul 29, 2009
Differentiation of Human Embryonic Stem Cells into Dopaminergic Nerve Cells
Ref: E-176-2008/0 | Updated: Oct 11, 2017
Improved Antibodies Against ErbB4/Her4
Ref: E-171-2009/0 | Updated: Feb 4, 2013
Non-Invasive In Vivo MR Method to Image Salient Features of Nerves
Ref: E-079-2003/1 | Updated: Sep 15, 2015
Prevention and Treatment of Multiple Sclerosis (MS) by Administering E-Selectin
Ref: E-153-2005/0 | Updated: Jun 16, 2010
A Rapid Ultrasensitive Assay for Detecting Prions Based on the Seeded Polymerization of Recombinant Normal Prion Protein (rPrP-sen)
Ref: E-109-2007/1 | Updated: Sep 1, 2008
A Novel Pro-Apoptotic Protein, ARTS
Ref: E-062-2000/2 | Updated: Aug 1, 2008
Treatment of Alcoholism by Inhibition of the Neuropeptide Y Receptor
Ref: E-101-2004/0 | Updated: Aug 1, 2008
Treatment and Diagnosis of Cancer, Diabetes and other Disorders Using Adrenomedullin Peptides and Antibodies
Ref: E-206-1995/3 | Updated: Oct 6, 2015
Biologically Active Macrolides, Compositions and Uses Thereof
Ref: E-203-2000/0 | Updated: Jun 3, 2010
Coacervate Microparticles Useful for the Sustained Release Administration of Therapeutic Agents
Ref: E-116-2004/0 | Updated: Jun 29, 2017
Method of Treating or Preventing Oxidative Stress-related Diseases (stroke and neurodegenerative diseases, wound healing and cardiovascular diseases)
Ref: E-059-2006/0 | Updated: Jul 1, 2007
A Neuronal Avalanche Size (NAS) Assay to Screen for Cognitive Enhancers and Anti-Epileptics
Ref: E-294-2005/1 | Updated: Sep 24, 2015
Identification and Isolation of the Receptor for Pigment Epithelium-derived Factor (PEDF)
Ref: E-314-2003/0 | Updated: Mar 1, 2007
Serotonin-Deficient Knock-out Mouse
Ref: B-019-1999/0 | Updated: Nov 18, 2015
Novel Treatments for Autoimmune Neuroinflammatory Diseases including Multiple Sclerosis
Ref: E-295-2005/0 | Updated: Jun 16, 2010
Novel Treatment of Vascular Cognitive Impairment
Ref: E-271-2005/0 | Updated: Sep 1, 2006
Beta-Amyloid and Tau Fibril Positron Emissions Tomography (PET) Imaging Agents
Ref: E-156-2006/0 | Updated: Aug 17, 2016
Monoclonal Antibodies Which Specifically Bind to the Ligand Hepatocyte Growth Factor (HGF) and are Useful in the Treatment of Cancer
Ref: E-262-1999/1 | Updated: Mar 1, 2006
Genes For Niemann-Pick Type C Disease
Ref: E-122-1997/0 | Updated: May 15, 2016
Rapid Anti-Depressant Response Produced by Low Dose Treatment with Anti-Muscarinic Drugs
Ref: E-175-2004/0 | Updated: May 24, 2016
Novel Methods for Reducing Inflammation and Treating Diseases such as Parkinson's and Alzheimer's Disease
Ref: E-130-2004/0 | Updated: Nov 4, 2015
AAV4 Vector and Uses Thereof
Ref: E-071-2000/0 | Updated: Dec 1, 2004
AAV5 Vector for Transducing Brain Cells and Lung Cells
Ref: E-072-2000/0 | Updated: Dec 1, 2004
New Derivative of Dextromethorphan for Use in Neuronal Therapy
Ref: E-158-2003/1 | Updated: Nov 4, 2009
Stem Cell Factor (SCF) Stimulates Neural Stem Cell Migration to Sites of Brain and Spinal Cord Injury
Ref: E-035-2004/0 | Updated: Jun 1, 2004
Pain Control by the Selective Local Ablation of Nociceptive Neurons
Ref: E-109-2000/0 | Updated: Dec 1, 2003
Anti-sera Against Arylalkylamine N-acetyltransferase (AANAT) - The Melatonin Rhythm Enzyme
Ref: E-181-2000/0 | Updated: Oct 5, 2015
Enhanced Distribution of Therapeutic Agents After Local Delivery
Ref: E-206-2000/0 | Updated: May 1, 2002
Batrachotoxins as Unique Activators of Sodium Channels
Ref: | Updated: Sep 1, 2001
Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof
Ref: E-141-2000/0 | Updated: Jun 15, 2010
Novel Inhibitors of p53 for Treatment of Neurodegenerative Disorders, Myocardial Infarction and Other Tissue Insults
Ref: E-222-2000/0 | Updated: Jun 14, 2010
Use of E-Selectin Tolerization as Treatment for Immunological and Vascular-Related Disorders
Ref: E-237-1999/0 | Updated: Apr 19, 2016
Immunoglobulin-G Constant Region Fusion Proteins as Molecular Weight Markers
Ref: | Updated: Dec 1, 2000
PTH2 and PTH1 Receptor Ligands
Ref: E-123-1999/0 | Updated: Nov 18, 2015
Process for Preparing 17-Alpha-Acetoxy-11-Beta-[4-(N,N-Dimethylamino)phenyl]-21-Methoxy-19-Norpregna-4,9-Diene-3,20-Dione, Intermediates Useful in the Process, and Processes for Preparing Such Intermediates
Ref: E-013-2000/0 | Updated: Aug 1, 2000


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